- What is Maturity-Onset Diabetes of the Young?
- Next generation sequencing of all known MODY genes
Next generation sequencing of all known MODY genes
A new test for all MODY genes
New DNA sequencing technology allows us to test for mutations in all the known MODY genes in a single test rather than analysing just one or two genes at a time. This targeted next generation sequencing test simultaneously analyses 25 genes in which mutations have been reported to cause MODY or another monogenic form of young-onset diabetes such as MIDD (maternally inherited diabetes and deafness) or partial lipodystrophy. Testing for mutations in multiple genes increases the number of patients in whom a monogenic form of diabetes is identified (Ellard et al 2013 Diabetologia 56: 1958-1963 http://link.springer.com/article/10.1007%2Fs00125-013-2962-5).
Which genes/genetic subtypes are included in the test?
When should I request this test and how much does it cost?
What sample is required?
What is the reporting time for this test?
Can the test identify a mutation that is known to cause a disease other than diabetes?
What are the test limitations?
Where can I find more technical information about the test?
Genetic Test Referral Forms