Diabetes Genes

Next generation sequencing of all known MODY genes

A new test for all MODY genes

New DNA sequencing technology allows us to test for mutations in all the known MODY genes in a single test rather than analysing just one or two genes at a time. This targeted next generation sequencing test simultaneously analyses 25 genes in which mutations have been reported to cause MODY or another monogenic form of young-onset diabetes such as MIDD (maternally inherited diabetes and deafness) or partial lipodystrophy. Testing for mutations in multiple genes increases the number of patients in whom a monogenic form of diabetes is identified (Ellard et al 2013 Diabetologia 56: 1958-1963 http://link.springer.com/article/10.1007%2Fs00125-013-2962-5).

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