Diabetes Genes

Hepatic Nuclear Factor 1 Alpha (HNF1A)

HNF1A is a gene which acts as a switch that turns on and off other genes in the body. Changes in the HNF1A gene cause diabetes by lowering the amount of insulin that is produced by the pancreas. It allows insulin to be produced normally in childhood but the amount of insulin reduces as you get older. HNF1A is the commonest cause of monogenic diabetes in the UK and accounts for approximately 50% of cases.

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