The diabetes caused by HNF4A tends to occur in childhood or early adulthood although some people may not be diagnosed until middle or old age. There is often an increasing need for treatment as you get older and so most affected individuals will go on to need either tablets or insulin to stop their blood glucose becoming too high. It is important to keep blood glucose controlled as (as with other types of diabetes) changes in the HNF4A gene can affect the small blood vessels in the eyes and the kidneys. This can be prevented if blood glucose levels are kept well controlled. Babies who inherit the HNF4A gene often have a high birth weight (over 4 KG) and may have low blood sugars early in life (neonatal hypoglycaemia) needing treatment. Therefore it is important to tell your doctor as soon as you are pregnant if you or your partner have a change in the HNF4A gene as this should alter how the pregnancy is monitored.
Information About HNF4A and Pregnancy
Individuals with HNF4A MODY may be sensitive to the blood glucose lowering effects of a group of drugs called sulphonylureas. Sulphonylureas include drugs like Gliclazide, Glipizide, Glibenclamide and Tolbutamide, they work by stimulating the pancreas to produce insulin. Early after the diagnosis of diabetes control is often better with sulphonylurea tablet treatment than with insulin, though as diabetes progresses with time insulin may be needed. People with HNF4A MODY who have been taking insulin from diagnosis of diabetes prior to genetic testing may be able to stop insulin and convert to sulphonylurea tablet treatment instead. Keeping physically active and slim is also important as this helps to keep the blood glucose controlled. This is no different from the advice we would give to anybody with diabetes.
It is very likely that a change in the HNF4A gene was also present in one of your parents and would have caused them to have diabetes as well. This does not mean that your diabetes will be identical to theirs and there can be considerable variation within the family. In particular, just because a parent or other family member has had ill health resulting from their diabetes, this does not mean that you will have a similar problem, particularly if your blood glucose is well controlled.
Approximately half the children born to a parent with HNF4A MODY will develop diabetes. This is due to the 50% chance of the affected gene being passed on from a parent at conception. Children and brothers and sisters of people with HNF4A MODY have a high chance of developing diabetes if they have inherited the change in the HNF4A gene from their parent. They are also at risk of low sugars soon after birth so babies whose parents have HNF4A changes (whether it is the mother or father affected) should have their blood glucose tested within 24 hours of birth. Family members of a person known to have HNF4A MODY should be aware of the symptoms of diabetes (such as thirst, passing a lot of urine or feeling very tired) and have their blood glucose measured if they are concerned that they may have it. Predictive genetic testing (to see if they have inherited the same change in the gene) is also possible – please see the section on predictive genetic testing on our website.
