MODY runs in families because of a change in a single gene which is passed on by affected parents to their children. We call this Autosomal Dominant Inheritance. All children of an affected parent with MODY have a 50% chance of inheriting the affected gene and developing MODY themselves.
MODY is caused by a change in a single gene. Mutations in the genes listed below account for 87% of the UK MODY.
HNF1A
HNF4A
GCK MODY
HNF1B MODY
KCNJ11 & ABCC8 MODY
Maternally Inherited Diabetes And Deafness (MIDD)
Changes in these different genes lead to different types of MODY. For more information about these different types of MODY please click on one of the above. There are still more genes to identify as 13% of MODY is not yet accounted for. Click here to download ATHtalk on diagnosing MODY For further information on the clinical implications of a diagnosis of MODY, the following is a useful review: Murphy R, Ellard S, Hattersley AT. Clinical implications of a molecular genetic classification of monogenic beta-cell diabetes. Nat Clin Pract Endocrinol Metab. 2008 Apr; 4(4):200-13.
For more information about MODY, please contact either:
Maggie Shepherd
+44 (0) 1392 408261
m.shepherd1@nhs.net
or
Professor Andrew Hattersley
a.t.hattersley@exeter.ac.uk
or
Contact your nearest Genetic Diabetes Nurse