Diabetes Genes

About Neonatal Diabetes

Neonatal Diabetes Mellitus (NDM) diagnosed before 6 months is a rare disease (approximate incidence of 1:100,000 live births) that reflects severe β cell dysfunction.

Two separate studies (Edghill et al., 2006b, Iafusco et al., 2002) have shown that diabetes diagnosed before 6 months of age is most likely to have a monogenic cause rather than being due to autoimmunity.

There are many different subtypes of neonatal diabetes defined by different genetic causes. Identifying the genetic causes of neonatal diabetes is not only relevant for patients, but also gives insights into which genes are needed for β cell formation and function.

Currently genetic testing finds a genetic diagnosis for over 85% of patients with neonatal diabetes. We provide genetic testing for neonatal diabetes for individuals with diabetes diagnosed before 9 months of age anywhere in the world and regardless of their current age.

July 2023: Patients Referred from 113 Countries