Diabetes Genes

Sulphonylurea Transfer In Patients With KCNJ11 And ABCC8 Mutations – TNDM

Guidance for transferring patients with a disease-causing variant in the ABCC8 or KCNJ11 gene causing transient neonatal diabetes (TNDM) and/or later adult-onset diabetes from insulin to a sulphonylurea


TNDM Transfer Protocol


We hope clinicians will follow the protocols outlined below and will then give us feedback on how the transfer went. We would request as much feedback as possible, especially if there are any problems as well as annual updates on patient treatment. For specific advice regarding individual patients please contact Prof Andrew Hattersley a.t.hattersley@exeter.ac.uk or Prof Maggie Shepherd on 01392 408261 m.h.shepherd@exeter.ac.uk.


Flanagan SE, Patch AM, Mackay DJ, Edghill EL, Gloyn AL, Robinson D, Shield JP, Temple K, Ellard S, Hattersley AT. Mutations in ATP-sensitive K+ channel genes cause transient neonatal diabetes and permanent diabetes in childhood or adulthood. Diabetes. 2007 Jul;56(7):1930-7. doi: 10.2337/db07-0043. Epub 2007 Apr 19. Erratum in: Diabetes. 2008 Feb;57(2):523. PMID: 17446535; PMCID: PMC7611811.

Bowman P, Flanagan SE, Edghill EL, Damhuis A, Shepherd MH, Paisey R, Hattersley AT, Ellard S. Heterozygous ABCC8 mutations are a cause of MODY. Diabetologia. 2012 Jan;55(1):123-7. doi: 10.1007/s00125-011-2319-x. Epub 2011 Oct 12. PMID: 21989597.

Bonnefond A, Durand E, Sand O, De Graeve F, Gallina S, Busiah K, Lobbens S, Simon A, Bellanné-Chantelot C, Létourneau L, Scharfmann R, Delplanque J, Sladek R, Polak M, Vaxillaire M, Froguel P. Molecular diagnosis of neonatal diabetes mellitus using next-generation sequencing of the whole exome. PLoS One. 2010 Oct 26;5(10):e13630. doi: 10.1371/journal.pone.0013630. PMID: 21049026; PMCID: PMC2964316.

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