Diabetes Genes

Glutamic Acid Decarboxylase (GAD65), Insulinoma Antigen 2 (IA-2) & Zinc Transporter 8 (ZnT8) Autoantibody Testing

Diagnostic Testing for Glutamic Acid Decarboxylase (GAD65 Ab), Insulinoma Antigen 2 (IA-2) & Zinc Transporter 8 (ZnT8) autoantibodies is Now Available at the Royal Devon and Exeter NHS Foundation Trust

Autoantibodies recognizing the islet cell antigens glutamic acid decarboxylase (GAD65), insulinoma antigen 2 (IA-2) and Zinc Transporter 8 (ZnT8) are present in up to 90% of newly diagnosed patients with type 1 diabetes (Wenzlau et al 2007 Proc Natl Acad Sci U S A 104: 17040-17045).  The prevalence of GAD, IA-2 & ZnT8 autoantibodies is less than 1% in GCK, HNF1A and HNF4A MODY, and testing for these autoantibodies close to diagnosis gives very good discrimination of Type 1 diabetes from MODY (McDonald et al 2011 Diabet Med 28: 1028-1033).  The Immunology department at the Royal Devon & Exeter NHS Foundation Trust offers a highly sensitive, automated ELISA method for the quantitative determination of GAD, IA-2 & ZnT8 autoantibodies in both serum and plasma samples.